Home etching of circuit boards, component placement, and ovens are common place.
However, 25nm printing might be out of the question.
According to Bluespec's website, you can designate a target processor, say a ARM cortex m9. You can then design your device around the chip. Then based on your fabrication capabilities, you could take the Verilog code and eventually get to a circuit board in your hands.
I am sure Bluespec would work well at the logic IC level.
I have been watching the progress of a hardware design language for thirty years. I am tempted to note the slowness of their progress, but then I remembered that software is in no better shap and it has been under development longer.
Still, progress is being made. I would love to see a home foundry where you define your ASIC, load the silicon and a magic box makes your circuit while you wait. I am sure the technology already exists to implement a home foundry box, granted I would not expect to do 25nm work, but surely the technology for the older foundrys could be adapted for simple homebuilt circuits. Especially given the state of SMD parts available.
Just a thought.