I tend to reach for Tina-TI (Texas Instruments), though I do use LTSpice (Analog Devices) as well. I think that slight bias mainly comes down to the user interface and the schematic capture side of things. Both are a bit infuriating, but Tina is slightly less infuriating than LTSpice. If I was doing something with LT parts, then it would be LTSpice regardless [because of their extensions to the standard SPICE stuff for their own devices].
I've been meaning to try out MPLAB Mindi (Microchip) for a while now, but haven't gotten around to it yet.
Explore GNURadio and get a glimpse of a world that most of us see as a bench full of different kinds of test equipment. How about making that bench with thousands of dollars of equipment, a computer screen. No need to worry about what happen to the test probes now
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