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Forum 美新型生物传感器可测细菌生长
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  • 生物传感器细菌生长
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美新型生物传感器可测细菌生长

启蒙19
启蒙19 over 14 years ago

作者:佚名 来源:中国医药报

 

近日,美国密歇根大学的研究人员发明出一种被称为“异步磁珠转动(AMBR)传感器”的新型生物传感装置。利用该装置,无需显微镜即可测量细菌的生长过程及药敏特征。研究人员表示,该装置或将有助于加快细菌感染治疗。研究结果已发表于1月15日的《生物传感器与生物电子学》期刊上。

领导这项研究的Raoul Kopelman教授解释说,异步磁珠转动传感器采用一种可以在磁场中异步旋转的磁性小珠,任何附着到这种磁珠上的物质都会降低其转速。“单个细菌附着上去后将极大地阻碍磁珠,使磁珠旋转速率减慢到原来的四分之一,随着细菌一点点长大,阻碍力将持续增大,磁珠转速也将随之变化,因而我们可测量出细菌的这种纳米级生长变化”。

利用同样的原理,该装置也可用于检测细菌的药敏性。当细菌受到药物影响停止生长,进而也会使得磁珠转速发生变化,于是研究人员便能在数分钟内知道药物是否对细菌产生了作用。

文章第一作者Paivo Kinnunen说:“采用这种方法,我们可以检测到小至80纳米的细菌生长变化,这远比一台光学显微镜管用——显微镜的解析度仅约250纳米。这种方法可以应用到任何微米级或纳米级的大小变化检测中。”

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