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Forum 神经荧光着色剂降低手术误伤神经风险
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  • 肌肉神经电探器
  • 神经荧光着色剂
  • 手术
Related

神经荧光着色剂降低手术误伤神经风险

启蒙19
启蒙19 over 14 years ago

来源:科技日报

 

 

 

image

这种荧光液体可以注射到患者体内,使患者体内的神经发光,从而让通常不可见的神经现形。

科学家研发出了一种荧光液体,可使外科医师在不借助经验和电子监控设备的前提下,看到患者体内最为纤细的神经。相关论文发表在最新一期《自然·生物技术》杂志上。

这种缩氨酸荧光液体由美国加利福尼亚州圣地亚哥医学院的一组研究人员开发,由包含氨基酸的蛋白质片段所组成。

研究人员将其注射入小鼠体内后发现,神经和机体其他组织间形成了显著的区别,被着色的神经在颜色上肉眼即可轻易识别,这将大幅减轻外科医生的手术压力。此外,该药剂的着色效果可持续2到8个小时,且无明显的副作用。研究人员还惊奇地发现,只要仍有血液供应,这种缩氨酸还能清晰的显示出已经损坏或被切断的神经。

论文合著者、加州大学药理学、化学以及生物化学教授钱永健说:“如果做一个比喻的话,这项技术就好比为要进行挖掘作业的工人提供了一张精确的地图,能清晰地显示出埋在地下的电缆位置。”

据了解,在手术过程中能否成功避开这些神经则是检验一个外科医生是否合格的重要因素,因为如果误伤则会导致长期疼痛或者瘫痪。目前,外科医生在手术中只能凭借自己长期积累的知识和经验以及肌肉神经电探器来确保他们不会伤到任何不必要的神经。这包括使用电极发现运动神经,但目前相关仪器还不能识别出那些更易受伤的细微神经。

论文合著者、美国加州大学头颈外科助理教授阮吴权(音译)说,对神经的保护往往是外科手术的优先考虑事项。例如,对于头颈手术而言如果神经遭受肿瘤侵犯,或者因手术对神经造成创伤或感染都有可能给患者带来严重后果。另据研究人员介绍,目前该新技术仍在逐步完善中,临床实验将在其得到充分验证后展开。

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