Wireless mouse stops working with disk on USB 3

Question

Wireless mouse stops working after connecting ssd disk on USB 3 on RASPI 4 B. When the USB 2 is used the wireless mouse works.

parasquid · Answer

I am guessing your wireless mouse operates on the 2.4ghz band.

There's some research showing evidence of interference between USB3.0 and devices operating on 2.4ghz https://www.intel.com/content/www/us/en/products/docs/io/universal-serial-bus/usb3-frequency-interference-paper.html

The whitepaper recommends shielding the noisy USB3.0 device, among other things:

Mitigation Methods
Shielding the USB 3 .0* Peripheral Device
As previously described in Section 3.1, noise due to the USB 3.0 data spectrum can radiate from a USB 3.0 peripheral device and its connector. Properly shielding the USB 3.0 peripheral device can help reduce the amount of noise emitted in the 2.4 GHz band. To illustrate this point, different areas of an external HDD were shielded, and for each case, noise emitted into the 2.4 GHz band was measured.

Or, as you have shown, you can just use the USB2.0 slots for the wireless mouse (it doesn't take so much bandwidth so that should be fine).